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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: IQCD All Species: 20
Human Site: S422 Identified Species: 62.86
UniProt: Q96DY2 Number Species: 7
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96DY2 NP_612460.1 449 52359 S422 L V R S L L R S K K K R G K G
Chimpanzee Pan troglodytes XP_509395 430 50032 S403 L V R S L L R S K K K R G K G
Rhesus Macaque Macaca mulatta XP_001111469 426 49461 S399 L V R S L L R S K K K R G K G
Dog Lupus familis XP_853808 436 51293 S400 L V R S M L K S R K K K R S K
Cat Felis silvestris
Mouse Mus musculus Q9D3V1 458 53332 S419 L V R S I L R S K K K K R G K
Rat Rattus norvegicus Q5XIR6 457 53238 S419 L V R S M L R S R K K K R V K
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_415294 409 46985 P386 L I R S T F K P K K K K K G K
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784878 482 56557 N466 K C R K A L K N K G K K G K K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.8 89.9 74.3 N.A. 66.1 66.5 N.A. N.A. 38.3 N.A. N.A. N.A. N.A. N.A. N.A. 38.3
Protein Similarity: 100 95 92.4 83.9 N.A. 80.1 80.3 N.A. N.A. 60.5 N.A. N.A. N.A. N.A. N.A. N.A. 61.2
P-Site Identity: 100 100 100 53.3 N.A. 66.6 60 N.A. N.A. 40 N.A. N.A. N.A. N.A. N.A. N.A. 40
P-Site Similarity: 100 100 100 80 N.A. 80 80 N.A. N.A. 60 N.A. N.A. N.A. N.A. N.A. N.A. 60
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 13 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 13 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 13 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 13 0 0 50 25 38 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 13 0 0 13 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 13 0 0 13 0 0 38 0 75 88 100 63 13 50 63 % K
% Leu: 88 0 0 0 38 88 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 25 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 13 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 13 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 100 0 0 0 63 0 25 0 0 38 38 0 0 % R
% Ser: 0 0 0 88 0 0 0 75 0 0 0 0 0 13 0 % S
% Thr: 0 0 0 0 13 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 75 0 0 0 0 0 0 0 0 0 0 0 13 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _